Trent Edwards completed 13 of 17 passes for 153 yards and C.J. Spiller scored twice as the Buffalo Bills won their only preseason game at Ralph Stadium, 35-20.

Buffalo (2-1) fell behind after Adam "Pacman" Jones returned the opening kickoff into Bills territory. Carson Palmer hit rookie tight end Jermaine Gresham and the Bengals had a quick lead.

The Bills got a drive going and Edwards hit Roscoe Parrish across the middle for a 12-yard score.

The Bengals got the lead back on a Palmer touchdown pass to Chad Ochocinco.

Spiller scored on a one-yard run and from 20 yards out to give the Bills the lead. Buffalo's offense scored the only touchdown of the third quarter, a 20-yard Ryan Fitzpatrick to David Nelson, their second hookup of the preseason.

Reggie Corner put it away in the fourth with a 20-yard interception return for a touchdown.

Buffalo wraps up the preseason on Thursday in Detroit. On Tuesday, the Bills will cut their roster down to 75.