After a good night sleep in a Buffalo area hotel, the Bills will face a desperate team. That is, unless the hotel staff takes the suggestion of Northtown's sign.

This is a big moment in the Bills season. The Patriots are in town, and hungry for a win after dropping their last two.

"It is the biggest game of our season so far and it is the game at hand," said Mario Williams. "That is the most important thing."

Sunday at 1:00, the Bills face a New England team that has not lost three straight games in almost a decade. It's a game that will, in part, come down to the pass rush. Tom Brady has struggled under pressure this season, and has been held to one touchdown pass in each of the last two losses.

"It is one of those things where for us to get where we want to get, we have to get pressure on (Brady)," Williams continued. "All of the games that he has played in, that you see them not come out on top, it is because he has been disrupted and is not comfortable. It is up to us to get after him and keep him moving."

The Bills are hopeful that Fred Jackson will be able to return for the game. He had limited participation in practice all week - is officially listed as questionable, along with C.J. Spiller. Their presence would go a long way, as the Patriots enter with the NFL's seventh best run defense. The surprise this year is that the Pats are in the bottom third of the league against the pass, playing significantly more man to man coverage.

"History you learn from, but it is not a predictor of the future," said Chan Gailey. "Every year is a new year and they are a totally different defense than they have been since I can remember. They are totally different and playing better."

"I think they go in and they are going to run their stuff," added Ryan Fitzpatrick. "They are going to give us whatever looks they want to give us. We are going to go and run our stuff and just go out there and execute.

"That is pretty much what we have learned. Everybody kind of does best. Let’s keep it simple. Go out there and do our stuff versus them doing theirs. See who wins."