The Bills can now look ahead to Washington after a win Friday in their first home preseason game.
Quarterback Kevin Kolb played the first half and finished 13-21 with 111 and an interception.
But it was rookie QB EJ Manuel who went 6-6 on the opening drive of the 2nd half and threw a touchdown to WR Brad Smith. Manuel sat after going 10-12 with 92 yards and that touchdown.
Buffalo's defense swarmed the quarterback all game long, which got to Minnesota's quarterbacks.. In the 1st half, linebacker Jamie Blatnick fell on a mishandled snap in the endzone to score the Bills other touchdown.
The Bills are 2-0 this preseason.